Process developments in the field of chemical, biotechnological and pharmacological processes currently face the problem that the complexity of the systems does not generally allow complete modelling and prediction. If a process is transferred from the laboratory to the production scale, it is aggravated by the fact that not all parameters can be transferred equally during scale-up, since size-dependent factors are sometimes in the denominator and sometimes in the numerator of important process parameters. Thus only one scale-up is possible, which considers as many key figures as possible, but not all equally. In addition to the physically founded equations and the equations obtained from dimensional considerations, many empirical equations are also used, especially in bioprocess engineering.
Within the framework of the iProcess research college, researchers from Bingen University of Technology, Trier University of Applied Sciences and Kaiserslautern University of Technology work closely together from all process areas to develop innovative process strategies using two model processes. The overall scientific goal of the application-oriented iProcess research college is to develop the process engineering fundamentals for using fungi and cyanobacteria as production organisms for pharmaceutically active substances. In particular, models are to be developed that are required for the design of the basic process engineering operations. These models will be developed at every stage of the entire process chain from cultivation in bioreactors to product separation. This is to be shown exemplarily by two process chains. The first is the production of protease inhibitors using fungi and the second is the production of polypeptide antibiotics using cyanobacteria.
Based on the research carried out so far on the optimisation of emers bioreactors, these are to be further improved by the working group and made usable for the fermentation of cyanobacteria in cooperation with the working group Prof. Ulber of the TU Kaiserslautern. The decisive factor here is an even supply of liquid within the reactor via the mist to be applied. CFD simulations are used to investigate and constructively implement optimization potentials for moisture distribution. Furthermore, the growth surface in the emersen reactors is to be enlarged.
|Consortium||Trier University of Applied Sciences (Environmental Campus Birkenfeld), TU Kaiserslautern, TH Bingen|
|Duration||November 2018 - October 2021|
|Supported by||State of Rhineland-Palatinate (Ministry of Science, Further Education and Culture) in the programme Forschungskollegs Rheinland-Pfalz for the promotion of cooperative doctorates|
|Funding amount||Share of the Trier University of Applied Sciences: 321,000 €|
Information about the project: https://www.mv.uni-kl.de/iprocess/